Cu(II) and Ni(II) Complexes of Sulfamethazine Mixed with Pyrimethamine: Synthesis, Characterization and Antimicrobial Study

Abstract

Two novel mixed ligand metal –drug complexes of sulfamethazine and pyrimethamine were prepared using CuCl2.2H2O and NiCl2.6H2O. The complexes were characterized by elemental analysis, melting point determination, molar conductivity, FT-IR and Uv-Visible spectroscopy. Based on the analytical and spectra data the complexes were formulated as [M(SUFPRM)Cl2.XH2O, (SUFPRM)=Sulfamethazine+Pyrimethamine, M=Cu, Ni. And the complexes formed possessed octahedral geometry. In the complexes, sulfamethazine and pyrimethamine acted as bidentate ligand coordinating through the sulfonamide N-atom and the pyrimidinicN-atom. The complexes have been tested in vitro against a number of pathogenic bacteria[g+][Eschericha coli, Proteus specie, Klebsiella pneumonia, Salmonella typhi and Bacillus]by using paper disc method. Obtained results indicated that the metal complexes exhibited better antimicrobial activities as compared to the ligand.